Beta Sheet Breaker Peptide

Sequence:  H-Asp-Ala-Pro-Ala-Ala-Pro-Ala-Gly-Pro-Ala-Val-Pro-Val–OH

M.W.  1132.3

Purity >95%

This beta sheet breaker peptide partly reversed in vitro the pathological prion protein to a biochemical and structural state similar to that of the physiological form.
Treatment of prion infectious material with this peptide delayed the appearance of clinical symptoms and decreased the infectivity by 90-95% in mice with experimental scrapie.
Such a peptide provides a useful tool to study the role of prion protein conformations and could represent a novel therapeutic approach for prion related disorders (1,2).

(1) Soto, C et al. (2000) Lancet 355, 192 Politopoulou et al. (2004) Protein and Peptide Letters, 11, 249-255

(2) Selvaggini, C et al.(1993) Bioch. Biophys. Res. Commun. 194, 1380