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Catalog Peptides  Retrocyclins Retrocyclin-100
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Retrocyclin-100
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Besides its antimicrobial activity, retrocyclin-1 protects human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as:
gp120 (KD = 35.4 nM)
CD4 (KD = 31 nM)
and galactosylceramide (KD = 24.1 nM) A.M.Cole et al., Proc. Natl. Acad. Sci. USA , 99, 1813 (2002)
W.Wang et al., J. Immunol. , 170, 4708 (2003)
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